While mouse embryonic fibroblasts expressing S51A-eIF2α are more sensitive to doxorubicin and HDACis than their wild-type counterparts, increased P-eIF2α mediates IL24-induced death of squamous cell carcinoma, an effect diminished upon the expression of S51A-eIF2α (34, 35). The gene discussed is EIF2A; the disease is squamous cell carcinoma.