From the subgroup analysis of Figures 7A, B, the pro-tumor role of GREM1 could be embodied in CD8+ memory T cell, Treg, and Th2 cell enriched groups, and B cell, CD4+ memory T cell, macrophage, Treg, and Th1 decreased groups, which illustrated the prognostic prediction of GREM1 in such immune cells increased or decreased infiltration conditions. The gene discussed is CD4; the disease is neoplasm.