In the past decades, cytokines and cytokine receptors have been extensively studied as cancer targets or cancer therapy by enhancing the growth inhibitory and immunostimulatory effects of interferons and interleukins, such as IL-2, IL-7, IL -12 and IL-15, or by inhibiting the inflammatory and tumor-promoting effects of cytokines such as TNF, IL-1β and IL-6 (10). This evidence concerns the gene IL1B and neoplasm.