A number of hepatocytes and HCC specific markers, including sialoglycoprotein receptor (ASGPR), hepatocyte paraffin 1 (Hep Par 1), and glypican-3 (GPC3), show a diagnostic and prognostic value (47, 50, 53, 86–88, 90). The gene discussed is GPC3; the disease is hepatocellular carcinoma.