As an example, OTUB1, a deubiquitinating enzyme overexpressed in gliomas, regulates SLC7A11, a critical inhibitory molecule in the ferroptosis Xc-system, directly through the ubiquitinase-proteasome degradation system, forming the OTUB1/SLC7A11 axis and thus promoting the stemness of glioma cells (54). The gene discussed is SLC7A11; the disease is glioma.