TGFB1 and cancer: The EMT event is orchestrated by the activation of various transcription factors (TFs) such as TWIST1/2, ZEB1/2, and SNAIL1/2 (102), growth factors (TGF-β and Hepatocyte growth factor (HGF), and inflammatory cytokines (TNF-α, CXCL12, IL-6, and IL-8), which, in turn, drive cancer cell invasion (103, 104).