Their findings show that CXCL6/CXCL8-CXCR1 chemotaxis arbitrates neutrophil recruitment and accumulation into the gastric TME, an event which upregulates the expression of CD54 and B7-H2 through the activation of the Extracellular signal-regulated kinase (ERK), Nuclear factor kappa B (NF-κB) pathway by tumor-derived TNF-α. The gene discussed is CXCL6; the disease is neoplasm.