MAPK8 and gastric cancer: (116) demonstrated that c-Jun N-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK)-dependent autophagy was connected to gastric cancer cell survival, and the inhibition of JNK/ERK-dependent autophagy enhanced the Jaspine B derivative-induced gastric cancer cell death through the p62/Keap1/Nrf2 signaling pathway.