LAG3 and melanoma: In 2021, a phase III study (RELATIVITY-047 trial) comparing the efficacy of nivolumab combined with the anti-lymphocyte-activation gene 3 (LAG-3) antibody relatlimab with that of nivolumab alone as first-line treatment for malignant melanoma was the first to show the significant benefit of adding an anti-LAG-3 antibody to standard immunotherapy.