Compared with other subgroups, bone metastatic breast cancer patients with ER-positive/PR-negative tumor tend to be older, whereas those with ER-positive/PR-positive and ER-negative/PR-negative ones were more frequently diagnosed in patients aged 49 years or younger; White race patients were more likely to have ER-positive tumor, while black race patients tended to have ER-negative tumors. This evidence concerns the gene ESR1 and neoplasm.