The earlier studies included few markers of severe form of dengue like plasmacytoid and dendritic cells (Pichyangkul et al. 2003), cytokines like IFN gamma (Tian et al. 2019), TNF alpha, IL 6 (Masood et al. 2018), IL 10 (Tian et al. 2019), MIF; chemokines like CXCL 10 (Masood et al. 2018); complements like C3a, C5a (King et al. 2020); proteases like tryptase and chymase (King et al. 2020). This evidence concerns the gene TNF and dengue disease.