(45) showed that the diffusion restriction feature was an independent predictor to help differentiate progressed HCC from low- or high-grade nodules because the expression of GPC-3 in HCC is obviously higher than that in low- or high-grade nodules; thus, the finding may confirm our results that marked diffusion restriction is also an independent predictor for GPC-3 positive expression. The gene discussed is GPC3; the disease is hepatocellular carcinoma.