GPC3 and hepatocellular carcinoma: For example, MRI specific superparamagnetic iron oxide (SPIO) anti-GPC-3 molecular probe has demonstrated the effectiveness for assessing GPC-3 expression in HCC tissues (14–16), and a few studies revealed the associations between GPC-3 expression with various MRI morphological features and quantitative parameters (e.g., MRI-based radiomics and iterative decomposition of water and fat with echo asymmetry and least squares estimation [IDEAL-IQ] parameters) (17–19).