CD4 and type 2 diabetes mellitus: As for Tregs in LADA, other investigators have reported increased expression of FoxP3 in CD4+CD25+T cells (44), or similar frequencies of CD4+CD25+CD127- FoxP3+Tregs among LADA, T1D, T2D and healthy controls (45).In contrast, in 2006, our team reported decreased FoxP3 mRNA expression in LADA patients (46).