In T2D patients, the frequencies of CD4+ T, Th17 and CD8+ Tcm cells were significantly increased with respect to NGT subjects (NGT vs. T2D:CD4+ T cells, p<0.01; Th17 cells, p<0.05; CD8+ Tcm cells: NGT vs. T2D, p<0.001; T2D vs. T1D, p<0.01, Figures 2H-J). This evidence concerns the gene CD4 and type 1 diabetes mellitus.