We speculate that the decreased frequencies of IFN-γ+CD4+ T and IFN-γ+CD8+ T cells in LADA and T1D patients may be due to the sequestration of these pathogenic cells in pancreatic lymph nodes (PLNs) after disease onset, which is supported by the persistence of diabetogenic T cells PLNs in NOD mice (36). This evidence concerns the gene CD8A and type 1 diabetes mellitus.