As for Tregs in LADA, other investigators have reported increased expression of FoxP3 in CD4+CD25+T cells (44), or similar frequencies of CD4+CD25+CD127- FoxP3+Tregs among LADA, T1D, T2D and healthy controls (45).In contrast, in 2006, our team reported decreased FoxP3 mRNA expression in LADA patients (46). This evidence concerns the gene CD4 and type 1 diabetes mellitus.