The frequencies of CD4+ Tem and CD8+ Tem cells were increased in T2D compared with the other three groups (CD4+ Tem cells: T2D vs. T1D, p<0.001, T2D vs. LADA, p<0.001, T2D vs. NGT, p<0.001; CD8+ Tem cells: T2D vs. T1D, p<0.001, T2D vs. LADA, p<0.001, T2D vs. NGT, p<0.001; Figures 3B, C). This evidence concerns the gene CD4 and type 1 diabetes mellitus.