In LADA patients, the frequencies of IFN-γ+CD4+ T, IFN-γ+CD8+ T and CD4+ Teff cells were comparable to T1D patients, but significantly decreased with respect to the NGT subjects (IFN-γ+CD4+ T: T1D vs. NGT, p<0.01; LADA vs. NGT, p<0.05; IFN-γ+CD8+ T: T1D vs. NGT, p<0.001; LADA vs. NGT, p<0.05; CD4+ Teff: T1D vs. NGT, p<0.01, LADA vs. NGT, p<0.05; Figures 2A-C). Here, CD4 is linked to type 1 diabetes mellitus.