CD274 and adenocarcinoma: Smokers or former smokers were predominantly of male sex and adenocarcinoma histology, without EGFR/ALK alterations, over 50% had PD-L1 TPS ≥ 50% and were also most commonly treated with IO as ≥ 2nd line (69.4% and 84.8%, for current and former smokers, respectively).