In this cohort, the most frequently mutated genes were EGFR (40%) and TP53 (27%), and, interestingly, except for three tumors, all had amplification or mutation in EGFR or MYC. An ingenuity pathway analysis (IPA) was performed integrating data from mutated genes and CNAs and the affected pathways were related to cancer, epithelial cell adhesion and HER2 signaling (44). The gene discussed is EGFR; the disease is cancer.