VCAM1 and Hepatic fibrosis: Our results indicate that i) LSEC VCAM1 promotes endothelial capillarization in two murine models of chronic liver injury, ii) toxic lipid-induced exuberant expression of VCAM1 promotes HSC activation via YAP1 signaling pathway, iii) endothelial cell-specific deletion of VCAM1 ameliorates CCl4-induced mouse liver fibrosis.