Their findings demonstrated that increased CelTIL score was associated with (1) upregulation of PD-L1 expression level and (2) higher infiltration of CD8+ or memory T cells in the tumor tissues, as well as higher CD8+ T cell to Treg ratio, which are all indicative of polarization toward pro-inflammatory response and amelioration of tumor-induced immunosuppression. This evidence concerns the gene CD8A and neoplasm.