Previous whole-exome sequencing (WES) and transcriptome sequencing of tumors identified several factors associated with ICB outcomes, such as high T/low myeloid cell infiltration (7), high B-cell (8)/CD4 memory T cell abundance (9), elevated PD-L1 expression (10), high tumor mutational burden (TMB) (11), and high similarity/diversity of TCR clonality (12, 13), which are associated with ICB responses. This evidence concerns the gene CD4 and neoplasm.