A z-stack analysis using confocal microscopy on uterine cross-sections from animals that experienced the LPS-induced abortion also showed lower expression of both claudin-2 and claudin-10 in IL-22−/− mice and provided a precise understanding of the localization of tight junctions (z-stack of claudin-2, z-stack of claudin-10, mp4). The gene discussed is IL22; the disease is abortion.