The most common TRAE were hand-and-foot syndrome (n = 37, 80.4%), abdominal pain (n = 32, 69.6%), nausea (n = 24, 52.2%), diarrhea (n = 21, 45.7%), fatigue (n = 19, 41.3%), hypertension (n = 13, 28.3%), hemoglobin decrease (n = 10, 21.7%), leukopenia (n = 7, 15.2%), elevated glutamic pyruvic transaminase (n = 6, 13%), thrombocytopenia (n = 5, 10.9%), itching (n = 5, 10.9%), and proteinuria (n = 5, 10.9%), but most of them were grade 1–2 TRAE. This evidence concerns the gene GPT and Hypertension.