Specifically, the superior diagnostic metrics associated with ALCAM, PF4 and properdin FE ratios in distinguishing clinically active LN and higher renal pathology AI, warrant further investigation of these 3 proteins as potential harbingers of renal injury in SLE, and predictors of short-term and long-term renal function in LN. The gene discussed is ALCAM; the disease is systemic lupus erythematosus.