Given that various types of cell death modalities (e.g. autophagy ferroptosis, etc.)were proven to be intimately associated with the eradication of tumors (9–11), we were inquisitive about the relationship between Cuproptosis and pancreatic adenocarcinoma (PAAD) for its exceptionally poor 5-year overall survival (OS) (12–20), and a striking fact that one of the Cuproptosis-related genes, CDKN2A, was a fully-investigated and well-known biomarker in PAAD at the same time. Here, CDKN2A is linked to pancreatic adenocarcinoma.