TP53 and neoplasm: As a result, the CRGI presented a significantly positive relationship with “cancer antigen presentation”, “recognition of cancer cells by T cells”, and “killing of cancer cells” in the cancer-immunity cycle, and “tumor proliferation signature”, “cellular response to hypoxia”, “EMT markers”, “apoptosis”, “DNA repair”, “DNA replication”, “G2M checkpoint”, “PI3K AKT mTOR pathway”, “MYC targets”, “P53 pathway”, “TGFβ”, “collagen formation”, and “ferroptosis” in the 19 known biological functions (Figure 6M).