Researchers identified IFN regulatory factor 3, as a crucial transcription factor for IFN-β expression, in transformed human myeloid cells infected with tumor-selective MRV, IFN-α/β receptor (IFNAR) signaling both gradually promoted IFN I secretion from infected cells by enhancing the activation of IFN regulatory factor 3, and also promoted viral replication. Here, IFNB1 is linked to neoplasm.