For instance, downregulation of deubiquitinating enzyme USP47 is associated with shorter disease-free survival of colorectal cancer (CRC) patients, and USP47-mediated deubiquitination of transcription elongation factor a3 can inhibit pyroptosis and apoptosis of CRC cells treated with chemotherapeutic doxorubicin, which may be a target for therapeutic intervention in CRC (59). This evidence concerns the gene TCEA3 and colorectal cancer.