With obesity as a risk factor and associated with worse clinical outcomes for breast cancer, Ryan Kolb put forward that activation of the obesity-associated NLRC4 inflammasome/interleukin-1β signal pathway drives disease progression via the adipocyte-mediated vascular endothelial growth factor A expression and angiogenesis (39). This evidence concerns the gene VEGFA and obesity due to melanocortin 4 receptor deficiency.