CD8A and neoplasm: Vps34 kinase inhibitor (Vps34i) can induce a T cell-inflamed tumor microenvironment construction (including infiltration of NK, CD8+, and CD4+ T effector cells) featured by high amplification of CCL5, CXCL10, and IFN-γ, thereby converting immune cold tumors (poorly infiltrated) into hot ones (highly infiltrated) (46).