SLFN5 and LFN13 are prognostic markers for GC, and SLFN family members SLFN5, SLFN11, SLFN12, SLFN12L, and SLFN14 are associated with immune cell infiltration and immune checkpoint expression in GC, which may promote GC progression by inhibiting T cell activation and thus mediating immune escape in GC. Here, SLFN5 is linked to gastric cancer.