report that patients with COVID-19 and aTB had decreased absolute lymphocyte counts (16), CD4+ T lymphocytes specific against SARS-CoV-2 (14) and polyfunctional CD4+ T lymphocytes (IFN-γ+, IL-2+, TNF-α+) (15), compared to patients with COVID-19 alone. This evidence concerns the gene CD4 and COVID-19.