At present, many immunotherapy-related areas have been well researched and explored through bibliometric analysis, such as the analyses of highly cited articles in programmed cell death protein 1 (PD-1) and programmed cell death ligand 1(PD-L1) immunotherapy (20), immunotherapy for hepatocellular carcinoma (21) and colorectal cancer (22), and emerging chimeric antigen receptor-based immunotherapy (23). This evidence concerns the gene CD274 and hepatocellular carcinoma.