IL1B and argyrophilic grain disease: Cytokines in the Th1, Th2, and Th17 cell differentiation pathways are often considered to be involved in AGD immune response, where downregulation is often a hallmark response for Th1, Th17, and Tregs pathways, whereas pro-inflammatory cytokines (Il-1β) and Th2 cytokines exhibit upregulation (3, 20).