Overexpression of TYMP in CRC or other malignancies and TYMP induced increased secretion of IL-10 and TGF-β in the TME, which inhibited the effector functions of DCs and increased CD8 T-cell exhaustion and conversion of effector T cells to Tregs, which are thought to be responsible for the creation of an immunosuppressive TME (19). The gene discussed is CD8A; the disease is colorectal carcinoma.