Ki-67 staining showed fewer proliferating cells (brown) in tumor tissues treated with a high dose (126 ± 15.3, n=8, Ki-67+ cells/field) than in those treated with 50 mg/kg/day (447 ± 28.68, P < 0.05; Figure 4G and S5A) or the control group (642 ± 15.59, P < 0.01). This evidence concerns the gene MKI67 and neoplasm.