IL1β, IL-2, IL-12, TNF-α, and IFN-γ, known as Th1 cytokines, are associated with good prognosis in many malignancies, whereas Th2 cytokines (IL-4, IL-5, and IL-10) are associated with tumor growth and metastasis (44, 45). The gene discussed is IL1B; the disease is neoplasm.