Systemic diseaseArthritisFever and skin rashDevelopment of MASTriggers Th1 response inducing the secretion of IFNγ by cytotoxic CD8+ and NK cellsSuppresses the synthesis of pro-IL-1β and pro-IL-18 via enhanced autophagy in monocytesInhibits the production of IL-1β, IL-6, and TNFα from monocytes induced by IFNγInhibits the activation of NLRP3 inflammasome in macrophages. This evidence concerns the gene CD8A and neoplasm.