Moreover, some associations of the HLA type with the clinical characteristics of AOSD, such as HLA-Bw35 and HLA-DRB1*14 with a mild, self-limiting disease; HLA-DRw6 with joint involvement; HLA-DRB1*1501 (DR2) and HLA-DRB1*1201 (DR5) with a chronic disease course; and HLA-DQB1*0602 (DQ1) with chronic and systemic disease, have also been shown (12–14). This evidence concerns the gene HLA-DRB1 and adult-onset Still disease.