NLRP3 and colitis: Another compound that may play anti-colitis role through regulating NF-κB and the NLRP3 inflammasome is Evodiamine (EVO), a bioactive component with anti-inflammatory role (61) derived from Evodia Rutaecarpa (ER), which is a herbal plant that has been used clinically in treating some human inflammatory diseases, especially for headache and abdominal pain (62).