As described above, regulation of the NLRP3 inflammasome using herbal compounds can affect the development of colitis via multiple mechanisms, whereas previous studies have shown that other inflammasome forming NLRs such as NLRP1, NLRP6, NLRC4 and AIM2 are also involved in the pathogenesis of colonic inflammation (110–113). This evidence concerns the gene NLRP1 and colitis.