NLRP3 and colitis: For instance, a study conducted by Lin et al (43) identified two compounds, wedelolactone and luteolin, from the bioactive fraction of Wedelia chinensis (WC) extracts, which has been proven to be effective in murine colitis model (88), and found that both compounds can suppress DSS induced colitis, and suppress the expression of NLRP3 and NLRP1 in the colon.