NFE2L2 and colitis: Another compound that may suppress colitis and NLRP3 inflammasome through Nrf2/HO-1 pathway is Toosendanin (TSN), a triterpenoid and natural insecticide with anti-inflammatory activity derived from Melia toosendan Sieb et Zucc (MTSZ), which is traditional herbal medicine used as parasiticide of digestive tract and agricultural insecticide in China (94).