This study found that the pyroptosis risk score correlated with immune checkpoints (such as CD274, CTLA4, and PDCD1), TIS score, and anticancer immune cycle enrichment score (such as release of cancer cell antigens, T cell recruitment, CD8 T cell recruiting, Th1 cell recruiting, NK cell recruiting), and TIICs (such as CD8 T cells, NK cells, Th1 cells, and dendritic cells) were positively correlated, suggesting that there is higher anticancer immunity in the TME of patients in the high-risk score group. Here, CD274 is linked to cancer.