Belizaire et al. demonstrated that increased LYN activation and interaction with mutant CBL promoted CBL phosphorylation, phosphoinositol 3-kinase regulatory subunit 1 (PIK3R1) recruitment and downstream phosphatidylinositol 3-kinase (PI3K)/AKT signal transduction, thereby promoting tumor progression [30]. Here, AKT1 is linked to neoplasm.