The positive pan-cancer correlations with m1A RNA methylation regulatory proteins YTHDF2 and ALKBH1, m5C methylation regulatory proteins DNMT1, DNMT3B, and ALYREF, and m6C RNA methylation regulatory proteins HNRNPC, HNRNPA2B1, and ELAVL1 were particularly significant. The gene discussed is ALYREF; the disease is cancer.