Figure 3(b) shows the types and loci of CDK1 gene alterations. We found that the “missense” mutation of CDK1 is the main type of genetic alteration. Changes in the Pkinase domain (R275Q) detected in colorectal cancer (COADREAD), BRCA, and GBM can induce a transcoding mutation of the CDK1 gene, which translates CDK1 from arginine (R) to glutamine (Q) at position 275. Subsequently, missense changes were found in CDK1 protein. The 3D structure of CDK1 showed the R275 site (Figure 3(c)). The gene discussed is CDK1; the disease is colorectal cancer.