From the current study, we found that LOX expression was positively related to macrophage infiltration and expression of M1 and M2 markers in ESCA tissues, but only the factors secreted by M2-type macrophages, which were mainly related to the promotion of the formation of the immunosuppressive environment (IL10, CCL2), angiogenesis (PDGFB), tumor proliferation (ARG1), and accelerating tumor recurrence and metastasis (EGF, TGF-β, CCL22, MMP2, MMP9, and MMP14), were significantly positively correlated with the expression of LOX [56]. The gene discussed is MMP9; the disease is neoplasm.