LOX and neoplasm: As clearly illustrated in Figure S5, there were significant statistical differences between groups in terms of histology type (p < 0.0001) (Figure S5A), age (p=0.0105) (Figure S5C), race (p=0.7060, p=0.034) (Figure S5D), alcohol consumption frequency (p=0.0062, p=0.0023) (Figure S5E), and tumor stage (Figure S5G) (p=0.0005, p=0.0009, p=0.1610), demonstrating that LOX methylation level is related to a series of essential clinical features.