EPHA2 and neoplasm: Subsequently, the experimental data from in vitro cell function experiments indicated that OE-EphA2-mediated the upregulation of EphA2 and reversed the inhibitory effect of anlotinib on VEGF and bFGF protein expression, as well as on proliferation, tumor angiogenesis, and migration, and on invasion abilities of TE-1R and KYSE-150R cells.