Of the 50 patients, 15 of the 38 patients who harbored MAP3K3 mutation and 5 of the 12 patients who harbored CCM gene mutation had repeated follow-up MRI scans before surgical resection (mean follow-up duration: 15.7 ± 24.4 months vs. 13.2 ± 15.8 months; p = 0.834). Here, MAP3K3 is linked to cerebral cavernous malformation.