Multivariate logistic regression analysis revealed that age (OR = 1.099, 95%CI: 1.012–1.193, P = 0.025), diabetes mellitus (OR = 2.679, 95% CI: 1.029–6.976, P = 0.044), white blood count (OR = 1.271, 95% CI: 1.028–1.572, P = 0.027), cystatin C (OR = 3.118, 95% CI:1.053–9.228, P = 0.040), and serum amyloid A (OR = 1.031, 95% CI: 1.009–1.054, P = 0.007) were independent risk predictors of PSCI in patients with lacunar infarction (Table 3). The gene discussed is CST3; the disease is diabetes mellitus.