Neuroprotective effects of PEA are mediated by peroxisome proliferator-activated receptor-alpha (PPAR-α) activation (Lo Verme et al., 2005) according to experimental evidence regarding PD, Alzheimer’s disease, traumatic brain injury and several neuropsychiatric disorders (Skaper et al., 1996; Genovese et al., 2008; Ahmad et al., 2012; D’Agostino et al., 2012; Esposito et al., 2012; Di Cesare Mannelli et al., 2013; Coppola and Mondola, 2013, 2014; Scuderi et al., 2014). Here, PPARA is linked to Alzheimer disease.