- Reduced levels of vitamin K-dependent coagulation factors, factors XI, XII, prekallikrein, and high molecular weight kininogen - Platelets hyporeactivity - Pre-existing conditions (thrombocytopenia in sepsis, reduced platelets production, and reduced levels of large multimers of vWf in cyanotic CHD). The gene discussed is VWF; the disease is Thrombocytopenia.