Plasma HOMA-IR levels in CS patients were positively correlated with BMI, FBG, TC, TG, LDL-C, insulin, glucagon, and hs-CRP levels, and negatively correlated with age, gender (male = 1, female = 2), HDL-C levels, negative factor scores, cognitive factor scores and PANSS total scores (P < 0.05). The gene discussed is INS; the disease is Cowden syndrome 1.