In another study, 93.8% of pediatric patients with moyamoya disease HTN had heterozygous or homozygous forms of the RNF213 p.r4810k variant, and the renovascular hypertension (RVH) to non-RVH ratio in patients with moyamoya disease hypertension (HTN) and homozygous variants of RNF213 p.R4810K was 8.3, also reflecting the possibility that the RNF213 p.r4810k variant may contribute to renal artery stenosis of RVH (6). The gene discussed is RNF213; the disease is hypertensive disorder.