NFKB1 and early-onset autosomal dominant Alzheimer disease: The results showed that the pathways mainly included Toll receptor signal pathway, NF-κB signal pathway, cAMP signal pathway, phosphatidylinositol signal pathway, complement coagulation cascade, cytokine receptor interaction, staphylococcus aureus infection, non-alcoholic fatty liver disease, platelet activation, Parkinson’s disease, Alzheimer’s disease, osteoclast differentiation, etc. (Figure 8B).