Both of Pmodel/sham and PEA/model were involved in NF-κB signaling pathway, cAMP signaling pathway, phosphatidylinositol signaling pathway, B-cell receptor signaling pathway, chemokine signaling pathway, cytokine receptor interaction, and other immune-related pathways, as well as some immune and inflammatory-related diseases, such as rheumatoid arthritis, primary immune deficiency diseases, staphylococcus aureus infection, and non-alcoholic fatty liver disease (Table 3). The gene discussed is NFKB1; the disease is rheumatoid arthritis.