Alzheimer’s disease (AD) is strongly associated with the accumulation of neurofibrillary tangles of hyperphosphorylated tau (p-tau) and the aggregation of amyloid β-42 (Aβ42) in the brain, which can be observed many years before the disease manifestation (Braak and Braak, 1997; Braak et al., 2011; Tarawneh and Holtzman, 2012; Villemagne et al., 2013; Cho et al., 2016). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.