In comparison with potassium voltage-gated channel subfamily C, member 1 (KCNC1) and member 3 (KCNC3), which were previously reported to be associated with DEE, progressive myoclonus epilepsy (MIM: #616187), and spinocerebellar ataxia (MIM: #605259) (Muona et al., 2015; Zhang and Kaczmarek, 2016), respectively, the linkage of the potassium voltage-gated channel subfamily C member 2 (KCNC2) gene and DEE remains poorly understood due to the scarcity of reported cases (Rademacher et al., 2020; Vetri et al., 2020; Rydzanicz et al., 2021; Schwarz et al., 2022). This evidence concerns the gene KCNC3 and developmental and epileptic encephalopathy.