Aβ and hyperphosphorylated tau (the pathological hallmark of AD) have been shown to activate the inflammasomes (NLRP1, AIM2 and NLRP3) and lead to GSDMD-mediated neuronal pyroptosis both in vitro and in vivo (Heneka et al., 2013; Tan et al., 2014; Han et al., 2020). The gene discussed is MAPT; the disease is Alzheimer disease.