Necroptosis activation and its positive correlation with Braak staging; inverse correlation with cognitive scores and brain weight. Co-localization of granular, incipient pTau aggregates with increased chaperone immunoreactivity. Inverse correlation of granulovacuolar degeneration with neuronal density in CA1 region of hippocampus and frontal cortex layer III. Upregulation in MLKL or p-MLKL along with elevated TNF-α? signaling in AD. Link between TNF signaling with necroptosis activation and neuronal loss in CA1-2 hippocampal neurons. The gene discussed is MLKL; the disease is Alzheimer disease.