In recent studies many key players like Beclin1, Atg1, p53, RIPK1, LC3, p62, TRIB3 play a pivotal role in switching between these death paradigms by toggling from one to the other cell death mechanism, cross communicating between various cell death pathways thus creating a complex scenario of cell death in various neurodegenerative diseases including AD (Saleem, 2021). This evidence concerns the gene ULK1 and Alzheimer disease.