Véronik Lachance, however, reported downregulation of various autophagy kinase complex components, e.g., BECN1-PIK 3C3, ULK1/2-ATG13-FIP200, and NRBF2 and this coincided with clinical dementia progression (CDR) in AD patients (Lachance et al., 2019). This evidence concerns the gene BECN1 and Alzheimer disease.