PIK3C3 and Alzheimer disease: Correia et al. (2015) stated that deficiency(ies) in autophagosome pathway precedes the formation of Aβ plaques or neurofibrillary tangles in AD. Lachance et al. (2019) demonstrated that deletion of NRBF2 (a component of the BECN1-PIK3C3 complex) reduced autophagy, led to impairment of memory in mice, altered long-term potentiation (LTP) and promoted accumulation of Aβ. Furthermore, overexpression of NRBF2 in the hippocampus rescued impaired autophagy and memory deficits and also reduced β-amyloid levels and improved memory in an AD mouse model (Lachance et al., 2019).