Accumulation of immature autophagic vacuoles in dystrophic neuritis. Autophagosomes with double membrane encapsulation around intracellular components. Coincidence of downregulated BECN1-PIK 3C3, ULK1/2-ATG13-FIP200, and NRBF2 with AD progression. Transcriptional upregulation of autophagy in entorhinal cortical region. Here, NRBF2 is linked to Alzheimer disease.