ACSL4 and neurodegenerative disease: Genetic studies have identified further that apart from Gpx and cystine/glutamate antiport, cellular iron transporters, iron-responsive element binding proteins, ferritin degradation, acyl-CoA synthetase long-chain family member 4 (ACSL4), lysophosphatidyl acyltransferase 3, NRF-2 pathway, etc., are important modulators of ferroptosis which have been implicated in various pathological conditions including cancer and neurodegenerative diseases (Cao and Dixon, 2016; Xu et al., 2019; Li J. et al., 2020).