Amyloid-β induced upregulation of NLRP1 inflammasome, NLRP1-mediated caspase-1-dependent ‘pyroptosis.’ Protection of Nlrp3–/– or Casp1–/– mice from spatial memory loss and other AD associated sequelae. Aβ1–42 induced pyroptosis, increased cell permeability and LDH release, Upregulated cellular GSDMD and p30-GSDMD expression, NLRP3 inflammasome and GSDMD-cleaved protein caspase-1 inflammatory factors levels. Inflammasome-mediated pyroptosis induced by hyperphosphorylated tau. Here, CASP1 is linked to Alzheimer disease.