It appears that at the cellular level in the AD brain, mitochondrial dysfunction, oxidative stress, abnormal accumulation of proteins (Aβ42, tau, etc.)with associated toxic effects and inflammatory response by microglia interact in a concerted manner mediating the pathogenesis of AD (Chakrabarti et al., 2015; Ganguly et al., 2017; Guo et al., 2020). Here, MAPT is linked to Alzheimer disease.