Indeed, genome-wide association studies have identified numerous genetic polymorphisms involved in NAFLD development and progression, e.g., patatin-like phospholipase domain-containing protein 3 (PNPLA3), membrane-bound O-acyltransferase domain containing 7 (MBOAT7), transmembrane 6 superfamily member 2 (TM6SF2), glucokinase regulator (GCKR), and others[64,65]. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.