Several studies, from our group and others, have linked CK1 and AD, both in relation to amyloid-Abeta peptide and the protein tau (Walter et al., 1998; Schwab et al., 2000; Yasojima et al., 2000; Pastorino et al., 2002; Flajolet et al., 2007). This evidence concerns the gene CSNK1A1 and Alzheimer disease.