Lopes-Coelho et al. (2016) found that hepatocyte nuclear factor 1β (HNF1) promotes glutathione synthesis to avoid carboplatin resistance in ovarian clear cell carcinoma. By studying ovarian cancer cell lines, including ES2, OVCAR3, OVCAR8, A2780, and A2780cisR, Nunes et al. (2018) clarified that cysteine protects cells from hypoxia and carboplatin effect to develop ovarian cancer. Santos et al. (2019) hypothesized that chemotherapy resistance of carboplatin could be reversed by disrupting cysteine metabolism. The gene discussed is HNF1A; the disease is ovarian cancer.