Although capillary morphogenesis protein 2 (CMG2) or anthrax toxin receptor 2 (ANTRX2) is the main mediator of anthrax toxicity (Liu et al., 2013a), TEM8/ANTRX1 was first identified as another target of anthrax toxin binding, specifically a site of binding of the protective antigen (PA) component of the anthrax toxin. This evidence concerns the gene ANTXR2 and anthrax infection.