Although this treatment paradigm was developed to target neuroendocrine neoplasms, recent advances in the understanding of lineage plasticity of neuroendocrine transformation in a variety of solid tumor types along with studies identifying widespread TEM8/ANTXR1 upregulation, suggest that SVV-001 has the potential to target many other tumor types that are particularly therapy-resistant and deadly. This evidence concerns the gene ANTXR1 and neoplasm.