Given that SVV-001 targets both well differentiated and high-grade neuroendocrine tumor, and that SSTR2 may be upregulated in the same tumors, one might hypothesize that SSTR2 may play a role in a specific type of tumor microenvironment characterized by upregulated TEM8/ANTXR1, low expression of type 1 IFN associated genes, immunosuppressive myeloid infiltration, and pathological tumor associated angiogenesis. This evidence concerns the gene ANTXR1 and neuroendocrine neoplasm.