In hepatocellular carcinoma (HCC) cell lines microRNA-493 suppressed tumor cell growth by targeting TEM8/ANTXR1 and R-Spondin 2 (RSPO2) and decreasing activation of the Wnt/β-catenin signaling pathway (Xu et al., 2017). This evidence concerns the gene RSPO2 and hepatocellular carcinoma.