Furthermore, the entire LH/PLOD family was found correlated with metastatization of solid tumors as hepatocellular and renal cell carcinomas (Xu et al., 2019; Yang et al., 2020), gliomas (Zhao et al., 2021), gastric (Li et al., 2020), and ovarian (Guo T. et al., 2021) cancers. The gene discussed is PLOD1; the disease is hereditary clear cell renal cell carcinoma.