PLOD3 and central nervous system cancer: The LH3/PLOD3 isoform was identified to be upregulated in glioma (Tsai et al., 2018; Baek et al., 2019), gastric cancer (Wang et al., 2019) and colorectal cancer (Deng et al., 2021; Shi et al., 2021), acting as a promoter of metastatization in different cancer types (Gong et al., 2021).