Phoenixin-14 alleviated high-fat diet-induced liver injury through activation of the AMP-activated protein kinase/Sirtuin1 and Erythroid 2-related factor 2/heme oxygenase-1 (NRF2/HO-1) pathways in experimental nonalcoholic fatty liver disease mice (Yang, et al., 2020). The gene discussed is HMOX1; the disease is metabolic dysfunction-associated steatotic liver disease.