NUCB2 and polycystic ovary syndrome: The nesfatin-1 level was lower in polycystic ovary syndrome (PCOS), and the decrease of nesfatin-1 may contribute to the mechanism governing PCOS, according the analysis of patients with PCOS (Demir Çaltekin et al., 2021) and animal model with PCOS (Xu et al., 2017).